Middle Sexes: Redefining He and She sensitively explores the controversial subject of the blurring of gender as well as the serious social and family problems - even dangers - often faced by those whose gender may fall somewhere in between male and female. Narrated by noted author Gore Vidal and filmed in the United States, Europe, Asia and South America, Middle Sexes examines the ways different societies and cultures handle the blurring of gender, sexual identity and sexual orientation. Through interviews with transgender, intersexual and bisexual men and women, as well as experts from the scientific and academic communities, the film considers the entire spectrum of sexual behavior, personal identity and lifestyles among people of different backgrounds and cultures. From this, a theme of tolerance and appreciation of diversity emerges in the film.